Journal
BIOCHEMISTRY-MOSCOW
Volume 80, Issue 10, Pages 1387-1392Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S000629791510020X
Keywords
acute ischemic myocardial injury; cell-free circulating mtDNA; cytolysis biomarkers; real-time PCR
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Funding
- Russian Academy of Sciences Presidium Program Fundamental Sciences for Medicine [FNM-15]
- Russian Academy of Sciences Presidium Program Fundamental Research for Development of Biomedical Technologies [2.1.12]
- Russian Foundation for Basic Research [15-04-05046, 15-54-16010]
- GDRI From Molecules to Cellular Events in Human Pathologies
- Siberian Branch of the Russian Academy of Sciences [59]
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Changes in the level of blood cell-free circulating mitochondrial DNA were examined during experimental adrenaline-induced myocardial injury in rats. The amount of mitochondrial DNA in the blood was significantly elevated at 48 and 72 h after subcutaneous injection of adrenaline solution, and it was accompanied by development of multiple smallfocal myocardial ischemia. This suggests that the measured level of blood cell-free circulating mitochondrial DNA might be used as a biomarker of acute myocardial ischemia.
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