Journal
JOURNAL OF STRUCTURAL CHEMISTRY
Volume 59, Issue 7, Pages 1674-1677Publisher
PLEIADES PUBLISHING INC
DOI: 10.1134/S0022476618070211
Keywords
complex; urease binding quenching mechanism; K-sv; K-q
Funding
- Natural Science Foundation of Shandong Province [ZR2016BL03]
- Scientific Research Foundation for Returned Scholars
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We have previously reported the synthesis, structure and urease inhibitory activity of a complex [Cu-2(L)(4)DMSO2] 2DMSO (HL = (E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylic acid), and we found the complex to show a strong inhibitory activity against jack bean urease [1]. In this study, the interaction of the complex and urease is studied by fluorescence spectroscopy. We find that the fluorescence quenching mechanism of the complex with urease is static quenching. The quenching rate constant (K-q) is 1.6 10(12) l/mol s( -1), the quenching constant (K-sv) is 1.6x10(4) l/mol, the association binding constant (K) is 3.55 10(4) l/mol, and the binding site number (n) is 1.22.
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