Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 6, Pages 3928-3932Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b11076
Keywords
liquid crystals; biopolymers; hydrogel sheets; bile acids; sensors
Funding
- US National Science Foundation [CBET-1264355]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1264355] Funding Source: National Science Foundation
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The development of simple, portable, and low-cost biosensing platforms is of great interest in the clinical diagnosis of disease. Here, we report liquid crystal (LC) droplet-embedded chitosan (CHI) hydrogel films formed by the Ag+ ion-triggered fast gelation of the CHI/surfactant complex-stabilized LC emulsion which is cast on substrates. The small sheets cut from the LC droplet-embedded hydrogel films combine the advantages of both hydrogels and LC droplets, offering a portable and label-free sensing platform for the real-time detection of bile acids in a small amount of solution. We find that the response time and detection limit of LC droplet-embedded hydrogel sheets for bile acids depend on their chemical structures.
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