Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 8, Issue 14, Pages 8900-8907Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b12031
Keywords
silica particles; vaterite particles; multicompartment structure; drug carrier; cancer therapy
Funding
- National Nature Science Foundation of China [21433010, 21320102004, 51303038, 21273055, 81402719, 21321063]
- National Basic Research Program of China [2013CB932800]
- National key foundation for exploring scientific instrument [2013YQ16055108]
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Vaterite particles are composed of particulate CaCO3 nano particles, which offer an ideal platform to synthesize architectures with hierarchical structure. Herein we show that mesoporous silica particles with well-defined multicompartment structure are fabricated by employing vaterite particles as templates. The obtained silica particles inherited the structure feature of vaterite and had excellent biocompatibility and biodegradability. Moreover, the silica particles were established as an efficient anticancer drugs carrier compared with hollow silica particles, which could be applied in cancer therapy in vitro and in vivo. The silica particles obtained here offer a cheap, facile, environmentally friendly avenue to assembly of hierarchical drugs carriers.
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