Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 122, Issue 45, Pages 10315-10319Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcb.8b08614
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Funding
- Tenure Track program at the Saitama University
- JSPS KAKENHI Grant [17K19097]
- Grants-in-Aid for Scientific Research [17K19097] Funding Source: KAKEN
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A supported lipid bilayer (SLB) is a versatile platform for examining the dynamical properties of biomembranes. However, the effect of a prerequisite solid substrate on the dynamics of a SLB remains very elusive. Especially, it is not clarified how the diffusivity of each leaflet in a SLB is affected by the SLB solid substrate interaction. In this study, we applied two-dimensional fluorescence lifetime correlation spectroscopy to a SLB for elucidating the diffusion of lipids in the proximal and distal leaflets of a SLB. We find that the autocorrelation curve of a fluorescent lipid in the proximal leaflet decays more slowly than that in the distal leaflet, meaning that the proximal leaflet is less diffusive. This result indicates stronger interaction between the proximal leaflet and a solid substrate.
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