Journal
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
Volume 189, Issue -, Pages 250-257Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2018.10.015
Keywords
Berberine; Silver; Nanoparticles; Acetaminophen; Streptozotocin; Histopathology
Categories
Funding
- Natural Science Foundation of Minhang District [2016MHZ2]
- Talent Training Plan Foundation of Shanghai Fifth People's Hospital affiliated to Fudan University [2017WYRCJY08]
- Foundation of Shanghai Key Specialty of Medicine [ZK2015B03]
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The current investigation was performed for the detailed analysis of protective effect of biofabricate berberine coated nano-silver ameliorate (BBR-AgNPs) on acetaminophen (APAP) induced hepato-renal damages in diabetic rats by blood biochemistry, tissue biochemistry, histopathological and immunohistochemical analysis. The spherical shaped BBR-AgNPs were synthesized by the Biofabrication technique and its physico-chemical characterizations done by different spectroscopic (UV-vis spectrophotometer, XRD spectroscopy, FTIR spectroscopy EDAX & DLS analyses) and microscopic (FE-SEM) techniques. The diabetic developed rats were administrated with APAP (2.0 g/5 mL/kg) and scrutinize its hepato-renal injuries. The synthesized BBR-AgNPs (75 mg/kg p.o) was administrated orally to the APAP-induced diabetic rats. The result of biochemical markers and lipid per oxidation were significantly (P < 0.05) increased in APAP-induced diabetic rats but decreased the level of antioxidants (P < 0.05), which results obtained in liver and kidney compared to the control group. Immunohistochemical studies result showed that the APAP-induced diabetic rats expressed a high immunoreactivity of nuclear transcription factor (NF-kB). Whereas, the acetaminophen-induced diabetic rats were treated with BBR-AgNPs renovated the changes in the above parameters analyzed. The results of the study clearly indicated that the BBR-AgNPs possess the antioxidant properties as well as anti-diabetic effects, furthermore, the acetaminophen-induced liver and kidney damage was probably inhibited by the inhibition of proinflammatory factor & NF-kB factors.
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