Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 879, Issue -, Pages 60-68Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2018.10.017
Keywords
Ferrocene; P-donor ligand; Copper complex; DNA binding; Anticancer agent
Categories
Ask authors/readers for more resources
In the present work, a new para-ferrocenylbenzoate copper(I) complex (a4) has been synthesized and characterized by numerous spectroscopic techniques such as: FT-IR, AAS, and CHNS analysis. Moreover, the single-crystal X-ray structure of the compound a4 was also explored. The DNA binding potency was determined by cyclic voltammetry, UV-visible spectroscopy, and viscometry. The redox behavior of the complex studied by cyclic voltammetry revealed a single quasi-reversible voltammogram, attributed to the dominant redox-active ferrocenyl moiety. The electrochemical study reveals that the complex binds to DNA non-covalently, the mode of interaction in particular, was found to be an electrostatic. The DNA binding constant was found to be 4.3 x 10(4) M- 1, which is very significant and impressive for non-covalent interactions, and is in close agreement with the UV-visible spectroscopic results. DFT/B3LYP method was used to ascertain the energies of frontier molecular orbitals (HOMO/LUMO) and the charge distribution on the molecular structure. The ferrocene-based copper(I) complex (a4) demonstrated to be a decent candidate in terms of cytotoxicity, although less active than that of the standard chemotherapeutic drug (cisplatin). (C) 2018 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available