Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 4, Pages 1757-1765Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b02259
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- IIT Kanpur, India
- UGC, India
- CSIR, India
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A simple and efficient one-pot three-component synthetic route to highly substituted and functionalizable piperazines in high yields with excellent stereoselectivity (de, ee >99%) is reported. The S(N)2-type ring-opening of N-activated aziridines by anilines followed by Pd-catalyzed annulation with propargyl carbonates gives rise to the final piperazine products.
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