Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 83, Issue 23, Pages 14457-14464Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b02223
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Funding
- JSPS KAKENHI [24655089]
- MEXT [S0901031]
- MEXT
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Azaspirene and related congeners, which possess various biological activities, have a unique spirocyclic core structure. However, there are few studies on the chemical properties of (-)-azaspirene, despite the fact that it may provide important insights into unveiling the biosynthetic pathway. Here, we report a nine-step chemical synthesis of an azaspirene analogue with a new finding that the natural (-)-azaspirene skeleton easily racemizes in neutral aqueous media.
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