Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 2, Pages 769-779Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b02609
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Funding
- DAE-BRNS (Young Scientist Research Award), India [37(2)/20/33/2016-BRNS]
- IIT-R
- SERB-NPDF, India [PDF/2017/002784]
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Herein we have developed a Ni-catalyzed protocol for the synthesis of linear ketones. Aryl, alkyl, and heteroaryl ketones as well as alcohols yielded the monoselective ketones in up to 90% yield. The catalytic protocol was successfully applied in to a gram-scale synthesis. For a practical utility, applications of a steroid derivative, oleyl alcohol, and naproxen alcohol were employed. Preliminary catalytic investigations involving the isolation of a Ni intermediate and defined Ni-H species as well as a series of deuterium-labeling experiments were performed.
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