4.7 Article

Enantioselective α-Aminophosphonate Functionalization of Indole Ring through an Organocatalyzed Friedel-Crafts Reaction

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 2, Pages 1094-1102

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b02843

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Funding

  1. Ministerio de Economia, Industria y Competitividad (MINECO) [GTO:2015-67871R]
  2. Gobierno Vasco (GV) [IT 992-16]

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Chiral phosphoric acids efficiently catalyze the asymmetric Friedel-Crafts reaction of several indoles with alpha-iminophosphonates to afford enantioenriched hybrid alpha-aminophosphonate functionalized indole derivatives.

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