Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 83, Issue 21, Pages 13011-13018Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b01513
Keywords
-
Categories
Funding
- CSIR [ESC0103, HCP010]
- DBT [GAP 346]
- DST [GAP 336, GAP 339]
- UGC
- J.C. Bose National Fellowship
- DBT
Ask authors/readers for more resources
Fluorescent active small molecules for organelle-specific bioimaging are in great demand. We synthesized 20 different pyrido-imidazo-indole fused heterocycles (6-5-5-6 ring) via copper catalyzed tandem N-arylation reaction in moderate to good yields. Due to decent fluorescent property, lysosome-directing moieties were attached on two of these heterocycles. Delightfully, those molecules tracked lysosome with bright blue fluorescence and colocalized with a known lysosome marker (Lysotracker Red) in human/murine cells. Therefore, it may be considered as a rapid (10 min) lysosome staining probe.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available