Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 83, Issue 21, Pages 13308-13324Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.8b02112
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Funding
- National Natural Science Foundation of China [21572154, 21772181, 81803344]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- Key R&D Project of Shandong Province [2018GSF118022]
- Fundamental Research Funds for the Central Universities [201612013]
- Qingdao Scientific and Technological Innovation Center for Marine Biomedicine Development Grant [2017-CXZX01-1-1]
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A metal-free formal [2 + 2 + 2] cycloaddition of functionalized ynamide-nitriles with ynamides is disclosed which offers highly efficient access to polysubstituted delta-carboline derivatives under the mediation of TfOH. This strategy is highly regioselective and chemoselective and displays mild conditions, high yields, and efficiency (within 1 min) in addition to substrates scopes (56 examples).
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