Journal
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
Volume 77, Issue 5, Pages 977-984Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.joms.2018.12.035
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Funding
- State of Sao Paulo Research Foundation (FAPESP) [2016/11419-0, 2016/02713-2]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [16/11419-0] Funding Source: FAPESP
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Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is characterized by cutaneous and/or mucosal ulcers in patients receiving immunosuppressive medication or with age-related immunosenescence. Its microscopic appearance often leads to a diagnostic challenge, sometimes mimicking an overt lymphoma. A 47-year-old woman, with a previous diagnosis of systemic lupus erythematosus, was referred for evaluation of a gingival ulcer, present for about 2 months and located in the maxillary peri-implant mucosa around implants, resembling peri-implantitis. An incisional biopsy was performed, and the microscopic evaluation showed a polymorphic infiltrate with some Reed-Sternberg-like cells. Immunohistochemistry showed positive findings for CD20, CD30, CD45, PAX-5, MUM-1, LMP-1 and EBER1/2, establishing the diagnosis of EBVMCU. After 2 months, total regression of the lesion was noted without any intervention. We discuss the possible association between the EBVMCU and systemic lupus erythematosus; to our knowledge, this is the first report of an EBVMCU simulating peri-implantitis. (C) 2019 American Association of Oral and Maxillofacial Surgeons
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