Journal
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
Volume 35, Issue 1, Pages 50-57Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/jop.2018.0067
Keywords
bimatoprost; eye drops; implant; ocular drug distribution; pharmacokinetics; preclinical
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Funding
- Allergan plc, Dublin, Ireland
- Allergan plc, Irvine, CA
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Purpose: To explore the ocular distribution of bimatoprost after intracameral administration of a biodegradable sustained-release bimatoprost implant (Bimatoprost SR) versus repeated topical administration of bimatoprost 0.03% ophthalmic solution in dogs. Bimatoprost SR and topical bimatoprost 0.03% previously were shown to have similar intraocular pressure-lowering effects in humans in a phase 1/2 clinical trial. Methods: Twenty-four beagle dogs received either once-daily topical bimatoprost 0.03% for 7 days or a bilateral intracameral administration of Bimatoprost SR (15g). At predetermined time points, ocular tissues were collected and concentrations of bimatoprost and bimatoprost acid were quantified using liquid chromatography-tandem mass spectrometry. Results: Bimatoprost SR administration enhanced delivery of study drug to a site of action [iris-ciliary body (ICB)] compared with topical bimatoprost (C-max [bimatoprost+bimatoprost acid]=18,200 and 4.13ng/g, respectively). However, distribution of drug to tissues associated with prostaglandin analog (PGA)-related side effects (i.e., bulbar conjunctiva, eyelid margins, and periorbital fat) was limited following Bimatoprost SR administration (C-max [bimatoprost+bimatoprost acid]=BLQ [beneath the limit of quantitation] to 0.354ng/g) compared with topical dosing (C-max [bimatoprost+bimatoprost acid]=36.6-2,110ng/g). Conclusions: Bimatoprost SR administration in dogs selectively delivered drug to the ICB with low or undetectable drug levels in ocular surface and extraocular tissues. Use of Bimatoprost SR for glaucoma treatment may reduce the incidence of adverse events typically associated with topical PGAs by targeting bimatoprost delivery to the key site of action of the PGA class and reducing exposure to off-target tissues.
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