Journal
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
Volume 61, Issue 2, Pages E33-E42Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JOM.0000000000001507
Keywords
gastrointestinal permeability; heat stress; heat shock protein 70; inhibitor; nuclear factor kappa-inhibitor alpha; intestinal fatty acid binding protein
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Funding
- University of New Mexico Overhead Funds Allocation Committee (OFAC) grant
- University of New Mexico Research Allocation Committee grant
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Objective: To examine the effect of oral glutamine supplementation on inflammation and fatigue during and after simulated wildland firefighting (WLFF) tasks in hot conditions over 2 consecutive days. Methods: Eleven men and women ingested a glutamine supplement or a placebo before and after simulated wildland firefighting in an environmental chamber (38 degrees C, 35% relative humidity). Subjective fatigue, markers of inflammation, and cellular stress were measured pre, post and 4 hours post-exercise on both days. Results: Gastrointestinal damage, subjective fatigue, and ratings of perceived exertion were lower after glutamine supplementation compared with placebo. Heat shock protein 70 (HSP70) and nuclear factor kappa-inhibitor alpha (I kappa B alpha) levels were higher on both days of the glutamine trial compared with placebo. Conclusions: Glutamine supplementation may improve recovery after fire suppression in WLFFs. This may result from the upregulation of HSP70 which inhibits inflammation and protects against gastrointestinal (GI) barrier damage.
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