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Nuclear Neuroimaging in Social Anxiety Disorder: A Review

Journal

JOURNAL OF NUCLEAR MEDICINE
Volume 59, Issue 12, Pages 1794-1800

Publisher

SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.118.212795

Keywords

social anxiety disorder; positron emission tomography; single photon emission computed tomography; functional neuroimaging; molecular imaging

Funding

  1. South African Medical Research Council
  2. Nuclear Technologies in Medicine and the Biosciences Initiative (NTeMBI)
  3. South African Medical Research Council under the MRC Clinician Researcher Programme
  4. Department of Science and Technology of South Africa

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In psychiatric research, nuclear imaging complements MRI. A recent neuroimaging review of social anxiety disorder focused predominantly on MRI, omitting the contribution of nuclear imaging methods. Nuclear imaging investigations of neural activity are sparse but have generally yielded results consistent with studies performed using MRI. Evidence for disturbances in neurotransmitter systems in social anxiety disorder is limited but suggestive of both serotonergic and dopaminergic dysfunction. Research focusing on additional molecular targets using existing and novel tracers, combined with recent technologic innovations and trends in collaborative methodology, may shape future nuclear imaging endeavors in this field.

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