Journal
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
Volume 31, Issue 4, Pages 366-377Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ANA.0000000000000554
Keywords
dexmedetomidine; neurosurgical anesthesia; neuroanesthesia; perioperative care
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Funding
- Beijing Municipal Administration of Hospitals' Youth Program [QML20160503]
- National Natural Science Foundation of China [1701038]
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The alpha 2-adrenergic receptor agonist dexmedetomidine has sedative, anxiolytic, analgesic, and sympatholytic effects. The potential advantages of neuroprotection, minimal impact on neuronal function, stable hemodynamics, opioid and anesthesia sparing effects, and minimal respiratory depression during awake procedures render it an effective anesthetic adjuvant in various neurosurgical settings. However, both the benefits and drawbacks of the use dexmedetomidine in neuroanesthesia should be considered. This narrative review will summarize the applications of dexmedetomidine in various neurosurgical settings, highlighting evidence regarding both its common and controversial uses.
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