Journal
JOURNAL OF NEUROSCIENCE
Volume 39, Issue 6, Pages 1066-1076Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2164-18.2018
Keywords
attention; efficacy; monosynaptic connection; receptive field properties; V1
Categories
Funding
- National Institutes of Health [NEI: EY013588, EY012576, EY018683, EY025219, EY023165]
- Whitehall Foundation
- Hitchcock Foundation
- Albert J. Ryan Foundation Graduate Fellowship
- National Science Foundation EPSCoR [1632738]
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Attention is a critical component of visual perception; however, the mechanisms of attention at the granular level are poorly understood. One possible mechanism by which attention modulates neuronal activity is to control the efficacy of communication between connected neurons; however, it is unclear whether attention alters communication efficacy across a variety of neuronal circuits. In parallel, attentional modulation of neuronal firing rate is not uniform but depends upon the match between neuronal feature selectivity and the feature required for successful task completion. Here we tested whether modulation of communication efficacy is a viable mechanism of attention by assessing whether it is consistent across a variety of neuronal circuits and dependent upon the type of information conveyed in each circuit. We identified monosynaptically connected pairs of V1 neurons through cross-correlation of neuronal spike trains recorded in adult female macaque monkeys performing attention-demanding contrast-change detection tasks. Attention toward the stimulus in the receptive field of recorded neurons significantly facilitated the efficacy of communication among connected pairs of V1 neurons. The amount of attentional enhancement depended upon neuronal physiology, with larger facilitation for circuits conveying information about task-relevant features. Furthermore, presynaptic activity was more determinant of attentional enhancement of communication efficacy than postsynaptic activity, and feed forward local circuits often displayed the largest facilitation with attention. Together, these findings highlight attentional modulation of communication efficacy as a generalized mechanism of attention and demonstrate that attentional modulation at the granular level depends on the relevance of feature-specific information conveyed by neuronal circuits.
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