Journal
JOURNAL OF NEUROCHEMISTRY
Volume 149, Issue 1, Pages 12-26Publisher
WILEY
DOI: 10.1111/jnc.14601
Keywords
cell-type diversity; cerebral cortex; gliogenesis; lineage progression; neurogenesis; radial glial progenitor cells
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Funding
- IST Austria institutional funds
- NO Forschung und Bildung [C13-002]
- Human Frontiers Science Program [RGP0053/2014]
- People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme (FP7/2007-2013) under REA grant [618444]
- European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Programme [725780 LinPro]
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The cerebral cortex is composed of a large variety of distinct cell-types including projection neurons, interneurons, and glial cells which emerge from distinct neural stem cell lineages. The vast majority of cortical projection neurons and certain classes of glial cells are generated by radial glial progenitor cells in a highly orchestrated manner. Recent studies employing single cell analysis and clonal lineage tracing suggest that neural stem cell and radial glial progenitor lineage progression are regulated in a profound deterministic manner. In this review we focus on recent advances based mainly on correlative phenotypic data emerging from functional genetic studies in mice. We establish hypotheses to test in future research and outline a conceptual framework how epigenetic cues modulate the generation of cell-type diversity during cortical development.
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