Neuropsychological outcomes of patients with low-grade glioma diagnosed during the first year of life

PurposeLow-grade gliomas (LGG) are a heterogeneous group of brain tumors, which are often assumed to have a benign course. Yet, children diagnosed and treated for LGG in infancy are at increased risk for neurodevelopmental disruption. We sought to investigate neuropsychological outcomes of infants diagnosed with LGG.MethodsBetween 1986 and 2013, 51 patients were diagnosed with LGG before 12months of age and managed at St. Jude Children's Research Hospital. Twenty-five of the 51 patients received a cognitive assessment (68% male; 6.83.3months at diagnosis; 10.54.8years at latest assessment). Approximately half the patients received radiation therapy (n=12; aged 4.0 +/- 3.0years at radiation therapy), with a median of 2 chemotherapy regimens (range=0-5) and 1 tumor directed surgery (range=0-5).Results The analyses revealed performance below age expectations on measures of IQ, memory, reading, mathematics, and fine motor functioning as well as parent-report of attention, executive, and adaptive functioning. Following correction for multiple comparisons, a greater number of chemotherapy regimens was associated with lower scores on measures of IQ and mathematics. More tumor directed surgeries and presence of visual field loss were associated with poorer dominant hand fine motor control. Radiation therapy exposure was not associated with decline in neuropsychological performance.Conclusions Children diagnosed with LGG in infancy experience substantial neuropsychological deficits. Treatment factors, including number of chemotherapy regimens and tumor directed surgeries, may increase risk for neurodevelopmental disruption and need to be considered in treatment planning.