Journal
JOURNAL OF NATURAL PRODUCTS
Volume 81, Issue 10, Pages 2259-2265Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.8b00576
Keywords
-
Funding
- National Natural Science Foundation of China [81803376, 81473116, 81673319, 81673670]
- Science and Technology Planning Project of Guangdong Province [2016A030303011, 2016B030301004]
- Science and Technology Planning Project of Guangzhou City [201707010399]
- Natural Science Foundation of Guangdong Province [2017A030313732]
- China Postdoctoral Science Foundation [2017M620405]
Ask authors/readers for more resources
Eight new matrine-type alkaloids, flavesines G J (1-4), alopecurine B (5), 7,11-dehydro-oxymatrine (6), 10-oxy-5,6-dehydromatrine (7), and 10-oxysophoridine (8), along with nine known analogues (9-17) were isolated from the roots of Sophora flavescens. Compounds 1-3 are the first natural matrine-type alkaloids with an openloop ring D, while compound 4 represents an unprecedented dimerization pattern constructed from matrine and piperidine, and 5 is the first example of a matrine-type alkaloid with cleavage of the C5 C-6 bond. The new structures were elucidated by means of spectroscopic data analysis (including NMR, MS, IR, and UV), and the absolute configurations were determined using singlecrystal X-ray diffraction and ECD data. The isolated alkaloids were evaluated for their antiviral activity against hepatitis B virus, and compounds 1, 4, 5, 10, and 14 exhibited comparable antiviral potencies to matrine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available