Journal
JOURNAL OF NANOPARTICLE RESEARCH
Volume 20, Issue 11, Pages -Publisher
SPRINGER
DOI: 10.1007/s11051-018-4415-z
Keywords
Hollow; Porous; Fluorescence; SiO2; Photodynamic therapy (PDT)
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Funding
- National Natural Science Foundation of China [21205026]
- Key Project of Natural Science Research of Universities in Anhui Province [KJ2018A0550]
- Fundamental Research Funds for the Central Universities
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This work reported a novel kind of CdTe quantum dot (QD) decorated mesoporous SiO2 (m-SiO2/QD) hybrid hollow nanoparticles for carrying photodynamic therapy (PDT) reagent. Both rod-like and spherical nanoparticles were prepared by using different shaped templates. Due to the porous shell and hollow interior, the hybrid m-SiO2/QD hollow nanorod with 360nm long and 120nm in diameter was selected for carrying zinc(II) phthalocyanine (ZnPc) photosensitizing molecules (61mg/g) since the generated reactive O-1(2) could be easily delivered out of the hollow particles through the porous shell (BET area 251cm(2)/g). It was found that the m-SiO2/QD-ZnPc hollow nanorods exhibited a good PDT activity and showed effective photocytotoxicity for the cancer cells. Because of the porous nature, fluorescence characteristic, and excellent storage ability, the m-SiO2/QD hybrid hollow particles possessed broad potential in the fluorescent labeled PDT.
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