Synthesis, structure interpretation, antimicrobial and anticancer studies of tranexamic acid complexes towards Ga(III), W(VI), Y(III) and Si(IV) metal ions

A new four tranexamic acid (TXA) complexes of some transition metal ions yttrium(III), tungsten(VI), and non-transition metal ion gallium(III) and silicon(IV) have been prepared. The TXA synthesized complexes have been characterized by molar conductance, magnetic susceptibility, infrared, electronic spectral, (HNMR)-H-1, thermal analyses, X-ray diffraction patterns, scanning and transmittance electron microscopies, and elemental microanalysis (C, H, N, and Cl). The study shows that these complexes have octahedral geometry with the formulas [Ga(TXA)(2)(Cl)(3)(H2O)], [Si(TXA)(2)(Cl)(4)]. [W(TXA)(2)(Cl)(2)]center dot Cl-2 and [Y(TXA)(2)(Cl)(H2O)]center dot 4H(2)O. Tranexamic acid complexes were formed in 1:2 (metal: ligand) stoichiometry. Based on the reported results, it may be concluded that in case of transition metal ions (tungsten(VI) and yttrium(III)) the deprotonated ligand (TXA) to tranexamate ion coordinated to metal -COO carboxylate ions as bidentate ligand through the oxygen atom of the carboxylate group and the nitrogen atom of the amino group -NH2, where the TXA ligand coordinated as a monodentate through the nitrogen atom of -NH2 group in case of non-transition metal ions. The metal complexes have been screened for their in microbiological activities against some kind of bacteria (G+ & G-) and fungi. For instance, in vitro anticancer activity of the gallium(III) complex was screened against the human hepato cellular carcinoma (HepG-2) tumor cell line. (C) 2018 Elsevier B.V. All rights reserved.