Journal
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 97, Issue 1, Pages 19-24Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00109-018-1723-9
Keywords
Osteoblast; Osteoclast; Circadian rhythm; Bone remodeling
Funding
- Natural Science Foundation of China [81270011, 81472125]
- Natural Science Foundation of Jiangsu Province [BK20151114]
- Foundation of Traditional Chinese Medicine of Jiangsu Province [YB201578]
- Fundamental Research Funds for Medical Innovation Center of Health and Family Planning Commission of Wuxi [CXTD006]
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The 24-h rhythm of behavioral and physiological processes is a typical biological phenomenon regulated by a group of circadian rhythm genes. Dysfunction of the circadian rhythm can cause a wide range of problems, such as cancer and metabolic diseases. In recent decades, increased understanding of the roles of circadian rhythm genes in the bone remodeling process have been documented, including osteoblastic bone formation, osteoclastic bone resorption, and osteoblast/osteoclast communication. A timely review of the current findings may help to facilitate the new field of circadian rhythmic bone remodeling research. Targeted pharmacological modulation of circadian rhythm genes is a possible therapeutic approach through which to overcome bone remodeling problems in the future.
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