Journal
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
Volume 53, Issue 5, Pages 797-802Publisher
ELSEVIER TAIWAN
DOI: 10.1016/j.jmii.2018.12.003
Keywords
Systemic lupus erythematosus; Pediatric-onset; Lupus nephritis; 5-methoxytryptophan (5-MTP); Retrospective cohort
Categories
Funding
- Ministry of Science and Technology of Taiwan [MOST 104-2314-B-182A-141-MY2, MOST 104-2321-B-400-001, 105-2321-B-400-001]
- Chang Gung University [CMRPD1D0411similar to3]
- Chang Gung Memorial Hospital [NMRPG3E6291-2, CMRPG3D1351similar to3]
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Background: This clinical study investigates the role of 5-methoxytryptophan (5-MTP) in pediatric systemic lupus erythematosus (SLE), with a particular interest in lupus nephritis (LN). Patients and methods: One hundred ten children with SLE were enrolled in the cohort study. Among the patients, seventy-seven (70%) had active LN and thirty-three (30%) were not present with LN during their first visit to the clinic. The diagnoses of LN were biopsy-proven. Serum samples were collected before and after administration of immunosuppressive medications to evaluate 5-MTP levels and regular laboratory data. Data were analyzed longitudinally. Results: Before any treatment started, patients with active LN had significantly higher 5-MTP levels as compared to patients with no LN (1.021 +/- 0.709 vs. 0.719 +/- 0.606, P = 0.0456). Also, in patient with active LN, 5-MTP level was significant decreased after treatment, compared with the levels before treatment (1.021 +/- 0.709 vs. 0.802 +/- 0.597, P = 0.0484). Patients who reached complete remission also had significantly higher initial serum 5-MTP levels than that in patients with no remission (1.244 +/- 0.784 vs. 0.846 +/- 0.556, P = 0.0488). There was an overall reduction in 5-MTP levels after six months of immunosuppressive treatment, regardless of the disease outcome. Subgroup analysis further revealed a significantly higher 5-MTP level during the active stage of LN (1.127 +/- 0.149 vs. 0.742 +/- 0.092, P = 0.0384). Conclusion: We demonstrated that serum 5-MTP level is positively correlated to the disease activity, prognosis, and remission status of pediatric LN in vivo. Copyright (C) 2019, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.
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