Journal
JOURNAL OF MICROBIOLOGY
Volume 57, Issue 1, Pages 74-79Publisher
MICROBIOLOGICAL SOCIETY KOREA
DOI: 10.1007/s12275-019-8514-z
Keywords
varicella zoster virus; antiviral; harringtonine; homoharringtonine
Categories
Funding
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2017R1D1A1B03032494]
- KIST Institutional Program [2E27832-18-106]
- NRF - Ministry of Education in Korea [2014H1A8A1021537]
- National Research Foundation of Korea [2014H1A8A1021537] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Harringtonine (HT) and homoharringtonine (HHT), alkaloid esters isolated from the genus Cephalotaxus, exhibit antitumor activity. A semisynthetic HHT has been approved for treatment of chronic myelogenous leukemia. In addition to antileukemic activity, HT and HHT are reported to possess potent antiviral activity. In this study, we investigated the effects of HT and HHT on replication of varicella-zoster virus (VZV) in vitro. HT and HHT, but not their biologically inactive parental alkaloid cephalotaxine (CET), significantly inhibited replication of recombinant VZV-pOka luciferase. Furthermore, HT and HHT, but not CET, strongly induced down-regulation of VZV lytic genes and exerted potent antiviral effects against a VZV clinical isolate. The collective data support the utility of HT and HHT as effective antiviral candidates for treatment of VZV-associated diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available