Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 105, Issue 5, Pages 873-880Publisher
WILEY
DOI: 10.1002/JLB.MR0618-213R
Keywords
HMGB-1; lps; nets; platelets; sepsis; thrombosis; TLRs
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Platelet TLR-4 activation by pathogen- or damage-associated molecular pattern molecules triggers pro-thrombotic, proinflammatory, and pro-coagulant effector responses. Moreover, platelet TLR4 has a prominent role as a sensor of high lipopolysaccharide circulating levels during sepsis and in the clearance of pathogens mediated by neutrophils. This review presents evidence pointing to TLR4 as a bridge connecting thrombosis and innate immunity.
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