Journal
JOURNAL OF IMMUNOLOGY
Volume 202, Issue 2, Pages 401-405Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1801349
Keywords
-
Categories
Funding
- National Institutes of Health [R01 AI039614, R01 AI103760, R37 AI027998, T32 AI007313, F31 AI133716]
- Dennis W. Watson Fellowship from the University of Minnesota Microbiology and Immunology Department
Ask authors/readers for more resources
The T follicular helper (Tfh) cell subset of CD4(+) Th cells promotes affinity maturation by B cells in germinal centers. The contribution of other Th cell subsets to B cell responses has not been fully explored in vivo. We addressed this issue by analyzing the T cell-dependent B cell response to the protein Ag PE in mice lacking specific Th cell subsets. As expected, PE-specific germinal center B cell production required Tfh cells. However, Tfh, Th1, or Th17 cell-deficient mice produced as many PE-specific, isotype-switched plasmablasts as wild-type mice. This response depended on Th cell expression of CD154 and Ag presentation by B cells. These results indicate that many Th cell subsets can promote plasmablast formation by providing CD40 signals to naive B cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available