Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 216, Issue 2, Pages 253-266Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20181965
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Funding
- Department of Defense Breast Cancer Research Program postdoctoral fellowship [W81XWH-13-1-0251]
- National Cancer Institute [R35 CA197588]
- Lustgarten Foundation [388207]
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Folate metabolism is crucial for many biochemical processes, including purine and thymidine monophosphate (dTMP) biosynthesis, mitochondrial protein translation, and methionine regeneration. These biochemical processes in turn support critical cellular functions such as cell proliferation, mitochondrial respiration, and epigenetic regulation. Not surprisingly, abnormal folate metabolism has been causally linked with a myriad of diseases. In this review, we provide a historical perspective, delve into folate chemistry that is often overlooked, and point out various missing links and underdeveloped areas in folate metabolism for future exploration.
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