Journal
JOURNAL OF DIABETES AND ITS COMPLICATIONS
Volume 32, Issue 12, Pages 1153-1159Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jdiacomp.2018.09.016
Keywords
Diabetes; Diabetic polyneuropathy; Corneal confocal microscopy; Diabetic complication; Toronto consensus criteria
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Funding
- Novo Nordisk Foundation [NNF14OC0011633]
- National Health Services in the County of Copenhagen in Denmark
- Danish Council for Strategic Research
- Danish Research Foundation for General Practice
- Novo Nordisk Foundation
- Danish Center for Evaluation and Health Technology Assessment
- Danish National Board of Health
- Danish Medical Research Council
- Aarhus University Research Foundation
- Novo Nordisk Scandinavia AB
- Pfizer Denmark
- Danish Diabetes Academy - Novo Nordisk Foundation
- Novo Nordisk UK: ASTRA Denmark
- GlaxoSmithKline Pharma Denmark
- National Health Services in the County of Aarhus in Denmark
- National Health Services in the County of Ringkobing in Denmark
- National Health Services in the County of Ribe in Denmark
- National Health Services in the County of South Jutland in Denmark
- Servier Denmark A/S
- HemoCue Denmark A/S
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Aims: In this cross-sectional study, we explored the utility of corneal confocal microscopy (CCM) measures for detecting diabetic polyneuropathy (DPN) and their association with clinical variables, in a cohort with type 2 diabetes. Methods: CCM, nerve conduction studies, and assessment of symptoms and clinical deficits of DPN were undertaken in 144 participants with type 2 diabetes and 25 controls. DPN was defined according to the Toronto criteria for confirmed DPN. Results: Corneal nerve fiber density (CNFD) was lower both in participants with confirmed DPN (n = 27) and in participants without confirmed DPN (n = 117) compared with controls (P = 0.04 and P = 0.01, respectively). No differences were observed for CNFD (P = 0.98) between participants with and without DPN. There were no differences in CNFL and CNBD between groups (P = 0.06 and P = 0.29, respectively). CNFD was associated with age, height, total- and LDL cholesterol. Conclusions: CCM could not distinguish patients with and without neuropathy, but CNFD was lower in patients with type 2 diabetes compared to controls. Age may influence the level of CCM measures. (C) 2018 Elsevier Inc. All rights reserved.
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