Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 128, Issue 11, Pages 4748-4750Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI124177
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Funding
- NIH [DK087893, HL128355]
- Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development Grant [BX000893]
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Renin-expressing cells have been conserved through evolution and maintain blood pressure and fluid homeostasis. Lack of availability of tools to study the specifics of renin regulation has limited advances in this field. In the current issue of the Journal of Clinical Investigation, Martinez and colleagues used the genome-wide assessment of the chromatin status of cells and uncovered a unique set of super-enhancers that determine the identity of renin cells. The renin super-enhancers play a key role in the molecular memory of renin cell function, a mechanism at the core of preserving homeostasis.
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