Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 234, Issue 6, Pages 7948-7956Publisher
WILEY
DOI: 10.1002/jcp.28014
Keywords
demethylases; m(6)A; methyltransferases; mRNA methylation
Categories
Funding
- National Natural Science Foundation of China [31572413]
- Natural Science Foundation ofZhejiang Province [LZ17C1700001]
Ask authors/readers for more resources
N-6-methyladenosine (m(6)A), as the most abundant RNA epigenetic modifications, has been shown to play critical roles in various biological functions. Research about enzymes that can catalyze and remove m(6)A have revealed its comprehensive roles in messenger RNA (mRNA) metabolism and other physiological processes. The readers including YTH domain-containing proteins, hnRNPC, hnRNPG, hnRNPA2B1, IGF2BP1, IGF2BP2, and IGF2BP3, which can affect the fates of mRNA in an m(6)A-dependent manner. In this review, we focus on recent advances in the research of the m(6)A modifications, especially about the latest functions of its writers, erasers, readers in RNA metabolism, cancer, and lipid metabolism. In the end, we provide insights into the underlying molecular mechanisms of m(6)A modifications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available