Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 234, Issue 5, Pages 5807-5826Publisher
WILEY
DOI: 10.1002/jcp.27506
Keywords
Mediterranean diet; metabolic syndrome; olive oil; polyphenols; resveratrol
Categories
Funding
- PO FESR 2014-2020 - Regione Campania, Asse 1 - obiettivo specifico 1.2, Progetto Sviluppo di nanotecnologie Orientate alla Rigenerazione e Ricostruzione tissutale, Implantologia e Sensoristica in Odontoiatria oculistica (SORRISO) [pdt1-000410]
- Project Studio di fattibilita per la progettazione di sistemi di rilascio nanoparticellari a base di idrossidi doppi lamellari (layered double hyroxide-LDH) in grado di veicolare, in modo controllato e prolungato nel tempo, molecole biologicamente attive [N. 0000836/2018]
- PON IAMP
- C 2014-2020 FESR progetto Micro/nanoformulati innovativi per la valorizzazione di molecole bioattive, utili per la salute e il benessere delle popolazione, ottenute da prodotti di scarto della filiera ittica (FORTUNA) [F/050347/03IX32]
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Metabolic syndrome (MetS) is defined as the co-occurrence of metabolic risk factors that includes insulin resistance, hyperinsulinemia, impaired glucose tolerance, type 2 diabetes mellitus, dyslipidemia, and visceral obesity. The clinical significance of MetS consists of identifying a subgroup of patients sharing a common physiopathological state predisposing to chronic diseases. Clinical and scientific studies pinpoint lifestyle modification as an effective strategy aiming to reduce several features accountable for the risk of MetS onset. Among the healthy dietary patterns, the Mediterranean diet (MedDiet) emerges in terms of beneficial properties associated with longevity. Current evidence highlights the protective effect exerted by MedDiet on the different components of MetS. Interestingly, the effect exerted by polyphenols contained within the representative MedDiet components (i.e., olive oil, red wine, and nuts) seems to be accountable for the beneficial properties associated to this dietary pattern. In this review, we aim to summarize the principal evidence regarding the effectiveness of MedDiet-polyphenols in preventing or delaying the physiopathological components accountable for MetS onset. These findings may provide useful insights concerning the health properties of MedDiet-polyphenols as well as the novel targets destined to a tailored approach to MetS.
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