Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 234, Issue 5, Pages 5564-5577Publisher
WILEY
DOI: 10.1002/jcp.27376
Keywords
apoptosis; autophagy; cell growth; DIRAS family members
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Funding
- National Natural Science Foundation of China [81372622, 81672362]
- Zhejiang Provincial Natural Science Foundation, China [LQ17H160009]
- Zhejiang Province Medical Science and Technology Project [2018276694]
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DIRAS family is a group of GTPases belonging to the RAS superfamily and shares homology with the pro-oncogenic Ras GTPases. Currently, accumulating evidence show that DIRAS family members could be identified as putative tumor suppressors in various cancers. The either lost or reduced expression of DIRAS proteins play an important role in cancer development, including cell growth, migration, apoptosis, autophagic cell death, and tumor dormancy. This review focuses on the latest research regarding the roles and mechanisms of the DIRAS family members in regulating Ras function, cancer development, assessing potential challenges, and providing insights into the possibility of targeting them for therapeutic use.
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