Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 234, Issue 8, Pages 12508-12515Publisher
WILEY
DOI: 10.1002/jcp.28110
Keywords
aerobic exercise; diabetic nephropathy; diabetic retinopathy; inflammation; nitric oxide; oxidative stress
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Diabetes mellitus is a highly prevalent metabolic disorder that affects many molecular pathways, causing a shift from a physiologic to a pathophysiologic state. Alterations in the molecular pathways promote diabetic complications and, thus, many medical and nonmedical therapies have been directed at preventing these complications. Despite the beneficial effects on moderating glycemic control, medical therapies may also have unfavorable side effects. This makes nonmedical therapeutic approaches more attractive due to lower pharmacological side effects of these strategies compared to medical agents. Aerobic exercise is now considered as a major nonmedical strategy that can promote beneficial and protective effects to counteract the development of diabetic complications via attenuation of the major molecular mechanisms involved in diabetes.
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