Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 120, Issue 4, Pages 5343-5354Publisher
WILEY
DOI: 10.1002/jcb.27812
Keywords
animal model; asthma; carvacrol; cytokines; flow cytometry
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Funding
- Mashhad University of Medical Sciences [901000]
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Th1, Th2, Th17, and Treg cells and their cytokine gene expressions in splenocytes of control mice, ovalbumin sensitized (S), and S treated with dexamethasone and carvacrol during a sensitization period were examined. Th2 and Th17 population as well as the gene expression of IL-4, IL-17, and TGF-beta were increased, but Th1, Th1/Th2 ratio, the gene expression of IFN-gamma and FOXP3 as well as the IFN-gamma/IL-4 ratio were decreased in S compared with control group (P < 0.001 for all cases). Carvacrol treatment caused significant reduction of Th2 and Th17 population as well as gene expression of IL-4, IL-17, and TGF-beta but increase in Treg cells, Th1/Th2 ratio, gene expressions of FOXP3, IFN-gamma, and IFN-gamma/IL-4 ratio (P < 0.05 to P < 0.001). The population of Th1, Th2, Th17 cells as well as the gene expression of IL-4, IL-17, and TGF-beta were significantly decreased, but only Treg was increased in the dexamethasone treatment group (P < 0.05 to P < 0.001). Carvacrol treatment during the sensitization period showed a more specific effect on Th1/Th2 imbalance in sensitized mice than dexamethasone, which may indicate the therapeutic potentials of carvacrol in disorders associated with Th1/Th2 imbalance such as asthma.
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