Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 120, Issue 5, Pages 7527-7538Publisher
WILEY
DOI: 10.1002/jcb.28027
Keywords
gastric cancer (GC); microRNA (miRNA); miR-129-5p; miR-129-3p; WW domain-containing E3 ubiquitin protein ligase 1 (WWP1)
Categories
Funding
- Basic Scientific Research Fund for Jilin University's Interdisciplinary Projects
Ask authors/readers for more resources
Gastric cancer (GC) is a worldwide health problem. Uncovering the underlining molecular mechanisms of GC is of vital significance. Here, we identified a novel oncogene WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) in GC. WWP1 could promote GC cell proliferation and migration in vitro and expedite GC growth in vivo. We also found out two microRNAs (miRNAs): miR-129-5p and -3p could both target WWP1. Interestingly, miR-129-5p bound to the CDS region of WWP1 mRNA. The miR-129 pairs (miR-129-5p and -3p) play pivotal roles in GC to suppress its proliferation and migration in vitro and slow down GC growth in vivo by repressing WWP1. In summary, we identified two tumor suppressive miRNAs which share the same precursor that could regulate the same oncogene WWP1 in GC. Our finding would add new route for GC research and treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available