Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 23, Issue 2, Pages 731-739Publisher
WILEY
DOI: 10.1111/jcmm.14101
Keywords
biomarker; cell communication; exosome; extracellular vesicles; kidney disease
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Funding
- National Key Research and Development Program of China [2018YFC1314000]
- National Natural Scientific Foundation [31671194, 81470922, 81720108007]
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Extracellular vesicles (EVs) are released to maintain cellular homeostasis as well as to mediate cell communication by spreading protective or injury signals to neighbour or remote cells. In kidney, increasing evidence support that EVs are signalling vesicles for different segments of tubules, intra-glomerular, glomerular-tubule and tubule-interstitial communication. EVs released by kidney resident and infiltrating cells can be isolated from urine and were found to be promising biomarkers for kidney disease, reflecting deterioration of renal function and histological change. We have here summarized the recent progress about the functional role of EVs in kidney disease as well as challenges and future directions involved.
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