Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 23, Issue 1, Pages 21-28Publisher
WILEY
DOI: 10.1111/jcmm.13930
Keywords
anxiety; berberine; bipolar disorder; depression; mechanism; pharmacology
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Funding
- Natural Science Foundation of China (NSFC) [81871070, 31571126, 31471120]
- Jilin Science and Technology Agency [20160307025YY, 20180519003JH, 20170414034GH, 20180414050GH]
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Berberine, a natural isoquinoline alkaloid, is used in herbal medicine and has recently been shown to have efficacy in the treatment of mood disorders. Furthermore, berberine modulates neurotransmitters and their receptor systems within the central nervous system. However, the detailed mechanisms of its action remain unclear. This review summarizes the pharmacological effects of berberine on mood disorders. Therefore, it may be helpful for potential application in the treatment of mood disorders.
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