Journal
JOURNAL OF CELL BIOLOGY
Volume 218, Issue 2, Pages 410-421Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201810084
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Funding
- National Institutes of Health [R01-DK089933]
- Society in Science - Branco Weiss fellowship
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Proper development of the human embryo following its implantation into the uterine wall is critical for the successful continuation of pregnancy. However, the complex cellular and molecular changes that occur during this post-implantation period of human development are not amenable to study in vivo. Recently, several new embryo-like human pluripotent stem cell (hPSC)-based platforms have emerged, which are beginning to illuminate the current black box state of early human post-implantation biology. In this review, we will discuss how these experimental models are carving a way for understanding novel molecular and cellular mechanisms during early human development.
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