4.6 Article

Development of gelatin/chitosan/PVA hydrogels: Thermal stability, water state, viscoelasticity, and cytotoxicity assays

Journal

JOURNAL OF APPLIED POLYMER SCIENCE
Volume 136, Issue 10, Pages -

Publisher

WILEY
DOI: 10.1002/app.47149

Keywords

biocompatibility; biomaterials; thermal properties; viscoelasticity

Funding

  1. Fondo Sectorial de Investigacion en Salud y Seguridad Social, SSA/IMSS/ISSSTE-CONACYT [234073]
  2. Ciencia Basica SEP-Consejo Nacional de Ciencia y Tecnologia (CONACyT) [CB-2015-01-258118]
  3. CONACyT

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Gelatin/chitosan/poly(vinyl alcohol) (PVA) hydrogels were fabricated with different polymer ratio using the freeze-drying process. The thermal stability, water state, rheological, and cytotoxic properties of the hydrogels were evaluated. Thermogravimetric/differential scanning calorimetry analyses showed a decomposition onset temperature below 242.7 +/- 2.7 degrees C. The samples did not show statistical differences (p < 0.05) on the onset temperature values. Nonfreezing water reached a constant value around of 1 g water/g polymer. Freezing water increased linearly with the increase of the water content independently of the polymer ratio. The hydrogels showed an equilibrium water content from 9 to 13 times their mass. The hydrogels exhibited a solid-viscoelastic behavior. The elastic modulus was higher with the increase of chitosan concentration (G ' = 22 170 +/- 85 Pa) independently of the temperature (5-55 degrees C). In vitro assay showed that hydrogels are nontoxic in the HT29-MTX-E12 cell line. These results indicate that the gelatin/chitosan/PVA hydrogels could be considered for biomedical applications. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47149.

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