Journal
JOURNAL OF ANTIBIOTICS
Volume 72, Issue 2, Pages 99-105Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/s41429-018-0115-2
Keywords
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Funding
- Department of Science and Technology, Science and Engineering Research Board (DST-SERB), Govt. of India [SR/SO/HS-104/2012]
- European Molecular Biology Organization (EMBO) [90 - 2016]
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Bioassay-guided screening of antibacterial compounds from the cultured marine Streptomyces sp. ICN19 provided Alageninthiocin (1), along with its known analogs geninthiocin (2) and Val-geninthiocin (3) and the indolocarbazole staurosporine (4). The structure of 1 was determined on the basis of 1D and 2D NMR spectra and ESI-HRMS. The absolute configurations of the amino acid residues were determined by enantioselective GC-MS analysis. Compound 1 exhibited potent activity against Gram-positive bacteria including Staphylococcus aureus, Bacillus subtilis, Mycobacterium smegmatis, and Micrococcus luteus, as well as cytotoxicity against A549 human lung carcinoma cells with an IC50 value of 6 nM.
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