Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 66, Issue 3, Pages 1245-1254Publisher
IOS PRESS
DOI: 10.3233/JAD-180779
Keywords
Demography; tissue and organ procurement; tissue banks; tissue preservation
Categories
Funding
- National Natural Science Foundation of China (NSFC) [81271239, 81771205, 91632113]
- Natural Science Foundation
- Major Basic Research Program of Shanghai [16JC1420500, 16JC1420502]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2017-I2M-3-008]
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The Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS/PUMC) Human Brain Bank was established in December 2012 and had accomplished 197 brain donations by November 2017. The brain bank was based on a large-scale willed body donation program in CAMS/PUMC starting from 1999. Demographic and medical characteristic analysis of brain donors was conducted to facilitate the construction of the brain bank. The average postmortem delay of brain donors was 17.7 h and 77.7% of these donors died less than 15 km away from the brain bank. Donors were predominantly with higher-level education (p < 0.001) and at an older age when registration (p < 0.001) and donation (p < 0.001) occurred. Our results elucidated the characteristics of donors in the CAMS/PUMC Human Brain Bank, which may provide useful information to target potential donors and improve the quality and quantity of brain specimens. The current study may pave the way for the construction of a nationwide network of standardized human brain banks in China.
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