Journal
BIOCHEMISTRY
Volume 54, Issue 13, Pages 2177-2180Publisher
AMER CHEMICAL SOC
DOI: 10.1021/bi5014062
Keywords
-
Categories
Funding
- National Natural Science Foundation of China (NNSFC) [51432001, 51372003, 21271004, 21271003]
Ask authors/readers for more resources
Here we have designed and synthesized a novel analogous cis-platinum complex (TDPt) with strong two-photon absorption properties and hight stability upon laser irradiation. Interestingly, a higher cytotoxicity against three types of cancer cells compared to that of commercial cis-platinum was observed. The initial confocal micrographs showed that lysosomes may be the biological targets of such TDPt, except the conventional presumed DNA. This hypothesis was further confirmed by the two-photon microscopy and transmission electron microscopy micrograph. These results form an important basis for future on-site observation of the anticancer mechanism of the Pt(II) complex.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available