Journal
IUBMB LIFE
Volume 71, Issue 4, Pages 442-455Publisher
WILEY
DOI: 10.1002/iub.2003
Keywords
vitamin E; microarray; gene expression profile; proteomics; metabolomics
Categories
Funding
- National Research Foundation (NRF) of Korea [NRF-2018R1D1A1B07049178]
- Research Fund, 2018 of the Catholic University of Korea
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Results from microarray analyzes have shown that both vitamin E deficiency and supplementation have a significant impact on the gene expression of various tissues and cells. Genes that were modulated by vitamin E supplementation were different depending on the tissue, which suggested that changes in gene expression are reflective of tissue function and the tissue-specific regulation of vitamin E. In addition, the magnitude of gene expression and types of genes whose expression was altered were differentially affected by the vitamin E forms used for intervention. Metabolite analyzes have provided better understanding of the vitamin E metabolic pathway and have established evidence for the regulation of energy, lipid, and glucose metabolism by vitamin E. However, there are a limited number of studies that have applied advanced genomics, proteomics, and metabolomics technologies to investigate vitamin E's biological functions and mechanisms of action. In this review, the effects of vitamin E on gene and protein expression investigated by microarray, transcriptome, and proteomics analysis are discussed. (c) 2019 IUBMB Life, 71(4):442-455, 2019
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