Journal
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Volume 95, Issue 7, Pages 892-899Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09553002.2019.1569777
Keywords
Radiation; stem cells; leukemia; hematopoiesis
Funding
- European Union Euratom Seventh Framework Programme RISK-IR project [323267]
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Studies of the responses of hematopoietic stem and progenitor cells (HSPCs) to low doses of ionizing radiation formed an important aspect of the RISK-IR project (www.risk-ir.eu). A brief overview of these studies is presented here. The findings confirm the sensitivity of HSPCs to radiation even at low doses, and illustrate the substantial impact that differentiation state has upon cell sensitivity. The work provides mechanistic support for epidemiological findings of leukemia risk at dose levels used in diagnostic CT imaging, and further suggests that low-dose irradiation may facilitate bone marrow transplantation, a finding that could lead to refinements in clinical practice.
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