Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 68, Issue 18, Pages 1099-1107Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2018.1534110
Keywords
Acrylic acid (AA); Hydroxyethyl cellulose (HEC); hydrogel; pH-responsive
Categories
Ask authors/readers for more resources
Polymers play vital role in drug delivery systems. Aim of current research work was to elucidate the effect of Hydroxyethyl cellulose (HEC), acrylic acid (AA) and N'N'-methylene bis-acrylamide (MBA) in formulation of pH sensitive nexus for targeted delivery of acid sensitive drug perindopril erbumine (PE). Different feed ratios were employed to prepare nexus via free radical polymerization. FTIR (Fourier transform infrared spectroscopy) depicts efficient grafting. Thermal parameters (DSC, DTA and TGA) were thermodynamically stable and morphological (SEM) analysis represented porous architecture. pH sensitivity was supported by on-off switching in acid and basic media. Hence, HEC-co-AA based design was encouraging for targeted delivery of perindopril erbumine.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available