Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 552, Issue 1-2, Pages 277-287Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2018.10.002
Keywords
AgNPs; Fe3O4; Chitin nanofibrous microsphere; Peroxidase-like activity; Synergetic antibacterial effect; Wound healing
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Funding
- Planning Subject of the Twelfth Five-Yea-Plan National Science and Technology for the Rural development of China [2013AA102203-05]
- National Natural Science Foundation of China [31660482, 21667018]
- Outstanding Youth Foundation of Jiangxi, China [20171BCB23010]
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In this study, a novel antibacterial agent was developed based on chitin nanofibrous microspheres loaded with AgNPs and Fe3O4 nanoparticles (Ag-Fe3O4-NMs) for synergistic antibacterial activity and wound healing. Ag-Fe3O4-NMs was prepared via an in situ synthetic method which showed an excellent porosity and wettability. Moreover, Ag-Fe3O4-NMs were capable of sustained release of Ag+ and catalysed the decomposition of low H2O2 concentrations to generate hydroxyl radical (center dot OH). The center dot OH and Ag+ showed higher antibacterial activity and inhibited the toxicity with high dose of AgNPs and H2O2. In vitro biocompatibility results suggested that Ag-Fe3O4-NMs have low toxicity and low hemolysis. Thus, a novel antibacterial agent with enhanced synergistic antibacterial activity was obtained by combination of Ag-Fe3O4-NMs and H2O2 at a low and biologlically safe dosage, which could facilitate fibroblast growth, accelerate epithelialization, and promote the healing rate of infected wounds.
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