Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 14, Issue -, Pages 519-529Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S184579
Keywords
microbubble; noninvasive therapy; double modal imaging; sonodynamic effects; synergistic ablation efficiency
Funding
- National Natural Science Foundation of People's Republic of China [81630047, 81471713, 81601513, cstc2018jcyjAX0747]
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Purpose: The objective of this study was to develop a multifunctional contrast agent for bioimaging and synergistic high-intensity focused ultrasound (HIFU) therapy to achieve theranostic. Materials and methods: A novel type of perfluorohexane-encapsulated fullerene (PFH-C-60) nanosphere was successfully developed via a vacuum ultrasonic emulsification and centrifugation method and subsequently used in ultrasound/computed tomography (CT) dual-modality and HIFU ablation of dissected bovine livers. In addition, transmission electron microscopic examination was employed to detect structural changes in the target tissue for HIFU ablation. Results: The use of composite nanospheres effectively enhanced ultrasound and CT imaging. Moreover, the HIFU ablation of dissected bovine livers was also significantly enhanced. Conclusion: Composite nanospheres demonstrate potential theranostic application as a multifunctional contrast agent for dual-modality biological imaging and highly efficient synergistic imaging-guided HIFU ablation.
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